The role of bile acids in human physiology has come into its own over the last decade. No longer are bile acids only known to be necessary for fat absorption, but they have critical roles in energy balance and metabolism as signaling molecules in the pathways regulating carbohydrate and lipid metabolism (e.g. FXR, TGR5, FGF 19). Additionally, bile acids play a vital role in modifying the gut microbiome that also is known to modify host metabolism.This symposium will review our current understanding of the role of bile acids in human physiology, with emphasis on their roles in mediating the beneficial effects of bariatric surgery, including non-alcoholic fatty liver disease in children and adolescents, as well as the vital place animal models play in helping us better understand bile acids physiology in obesity and metabolic diseases.


1:30pm Bariatric Surgery, Bile Acid Metabolism, and Fatty Liver Disease in Pediatrics
Marc P Michalsky, MD
2:00pm Bile Acid Physiology in Humans
John YL Chiang, PhD
2:30pm Animal Models of Bariatric Surgery and Alterations in Bile Acid Metabolism
Charles R Flynn, PhD