The liver is the “heart” of the metabolic soul. In the very near future the death of that soul through cirrhosis from non-alcoholic fatty liver disease (NAFLD) will be the most common indication for adult and pediatric liver transplants. The increasing prevalence of NAFLD disproportionately affects children, and it is now the leading cause of pediatric liver disease. Speakers in this session will take you from bench to bedside, reviewing the metabolic pathways involved with NAFLD and identifying potential behavioral and biochemical treatment targets. They will also explore the clinical manifestations and treatment options for NAFLD in pediatric and adult populations. This session really ‘de-livers’ on this increasingly important topic.