Background

Although the rate of metabolic syndrome (MS) rises with age in obese subjects, how age affects the response to intervention attempts to curb the MS remains largely unstudied. Here we focused on the role of age as a modulator of the effect of a structured 1year intervention program vis-a vis the achieved response of metabolic outcome, resting metabolic rate (RMR) and body composition (BC ) in MS.

Methods

A cohort of 75 obese patients (33/42 F/M) with MS, mean BMI 35.0±4.2 kg/m²; participated in a 12 months weight-loss program. Subjects were subdivided into three age groups: group 1: age 18-49 n=25. group 2: age 50-59 n=26. group 3: age 60-70 n=24. BC was evaluated by DEXA, RMR by indirect calorimetry, and MS components were assessed by standards measures. Measurements were recorded before and after 12 months. The RMR was adjusted per kilogram of body weight (RMR/kg).

Results

Overall, the achieved weight loss was negatively related to age, such that the younger the age, the greater the weight loss (r= -0.300 P<0.001). Additionally, the younger age group (I) was distinct in that 1) it was the only group in which RMR/kg rose at the end of a year, as the overall weight dropped (r=-0.527 P<0.05). 2) Testosterone increased as the weight dropped (r=-0.862 P<0.001); 3) Serum asymmetric dimethylarginine (ADMA) dropped proportionately to weight loss (r=0.512 P<0.05); 4) HbA1C dropped by 5%, (P<0.001).

Conclusions

Young patients lose more weight, fat mass, increased RMR/kg, improve testosterone status (men), and ADMA compared to adults.