Background

Menopause is one of the most important events in women life which changes the metabolism. While the correlation between metabolic syndrome and hyperuricemia in post-menopausal women has already been reported, the association in pre-menopausal women has not been studied. Thus, this study was designed to evaluate the association between hyperuricemia and metabolic risk components in Korean pre-menopausal women.

Methods

This study data was collected from the Korea National Health and Nutrition Examination Survey (KNHANES) 2016, which was conducted from January to December 2016. Total 2,958 (N=25,344,879) were examined among 4,305 women participants. A multiple logistic regression analysis was used to evaluate the association between hyperuricemia and metabolic risk components (by metabolic syndrome) in Korean pre-menopausal and post-menopausal women; presenting as odd-ratios (OR) with 95% confidence interval (95% CI).

Results

Among 2,958 participants, 57.6% (n=1,508) was pre-menopausal women. In pre-menopausal women, hyperuricemia was associated with abdominal obesity (OR 6.35, 95% CI 3.42-11.80, P<0.001), high blood pressure (OR 3.67, 95% CI 1.86-7.21, P<0.001), hypertriglycemia (OR 3.53, 95% CI 1.68-7.39, P=0.001), and impaired fasting glucose (OR 2.15, 95% CI 1.10-4.20, P=0.026). After adjustment (Model 3), it was significantly associated with abdominal obesity (OR 4.30, 95% CI 1.02-18.04, P=0.046), high blood pressure (OR 3.23, 95% CI 1.53-6.85, P=0.002), and hypertriglycemia (OR 3.08, 95% CI 1.40-6.78, P=0.005). In contrast, no metabolic risk was significantly associated with hyperuricemia in post-menopausal women.

Conclusions

In Korean pre-menopausal group, hyperuricemia was significantly associated with abdominal obesity, high blood pressure, and hypertriglycemia.