Background

The aim of this study was to investigate the association between mechanical properties of carotid artery and obesity and its related cardiometabolic profiles in Korean children and adolescents.

Methods

Cross-sectional data from 285 children and adolescents (mean age: 10.68 ±2.18, boys 40.4% ) who were enrolled for Intervention for Children and Adolescent via Activity and Nutrition(ICAAN) were used for analysis. The mechanical properties of carotid artery were directly measured in a cross-sectional image of common carotid artery using a velocity-vector imaging (VVI) analysis including instantaneous vessel area and deformation parameters as fractional area change (FAC), circumferential strain, and circumferential strain rate (CSR).

Results

Obesity status presented as BMI Z-score negatively correlated with CSR, whereas no significant correlation was found between BMI-Z score and carotid intima media thickness. Among vascular properties, CSR of carotid artery was negatively correlated with BMI Z-score(r=-0.29, p<0.001), age(r=-0.27, p<0.001), insulin resistance presented as HOMA-IR(r=-0.34, p<0.001), systolic(r=-0.28, p<0.001) and diastolic blood pressure(r=-0.27, p<0.001), hsCRP(r=-0.26, p<0.001), ratio of serum triglyceride to HDL-cholesterol (TG/HDL) (r=-0.25, p<0.001), and leptin(r=-0.36, p<0.001). CSR showed positive correlation with adiponectin(r=0.22, p<0.001). Multiple linear regression model showed significant association between CSR of carotid artery and age (β=-0.056, p<0.001), BMI Z-score (β=-0.144, p<0.001), and TG/ HDL (β=-0.049, p=0.003) in this population.

Conclusions

Obesity status is significantly associated with mechanical property of carotid artery in children and adolescents.