The aim of this study was to investigate the association between mechanical properties of carotid artery and obesity and its related cardiometabolic profiles in Korean children and adolescents.
Cross-sectional data from 285 children and adolescents (mean age: 10.68 ±2.18, boys 40.4% ) who were enrolled for Intervention for Children and Adolescent via Activity and Nutrition(ICAAN) were used for analysis. The mechanical properties of carotid artery were directly measured in a cross-sectional image of common carotid artery using a velocity-vector imaging (VVI) analysis including instantaneous vessel area and deformation parameters as fractional area change (FAC), circumferential strain, and circumferential strain rate (CSR).
Obesity status presented as BMI Z-score negatively correlated with CSR, whereas no significant correlation was found between BMI-Z score and carotid intima media thickness. Among vascular properties, CSR of carotid artery was negatively correlated with BMI Z-score(r=-0.29, p<0.001), age(r=-0.27, p<0.001), insulin resistance presented as HOMA-IR(r=-0.34, p<0.001), systolic(r=-0.28, p<0.001) and diastolic blood pressure(r=-0.27, p<0.001), hsCRP(r=-0.26, p<0.001), ratio of serum triglyceride to HDL-cholesterol (TG/HDL) (r=-0.25, p<0.001), and leptin(r=-0.36, p<0.001). CSR showed positive correlation with adiponectin(r=0.22, p<0.001). Multiple linear regression model showed significant association between CSR of carotid artery and age (β=-0.056, p<0.001), BMI Z-score (β=-0.144, p<0.001), and TG/ HDL (β=-0.049, p=0.003) in this population.
Obesity status is significantly associated with mechanical property of carotid artery in children and adolescents.