The long-term outcomes of single anastomosis duodeno-ileal bypass with sleeve gastrectomy (SADI-S) have never been reported in the literature. Aim: The aim of the study was to evaluate the long-term outcomes following SADI-S. Setting: Single private institute, USA.


Data from 626 patients who underwent a primary laparoscopic SADI-S from June 2013 through March 2019 by three surgeons were retrospectively analyzed.


Six hundred and twenty-six patients were included in the study. The mean age and preoperative body mass index (BMI) were 46.3 ± 12.9 yrs. and 49.5 ± 8.8 kg/m2, respectively. The average operative time and length of stay were 65.4 ± 8.3 mins and 1.6 ± 0.8 days, respectively. One hundred and eight patients were out five years. The overall intraoperative, short-term, and long-term complication rates were 0.3%, 6.3%, 8.1%, respectively. At five years, the DM, HLD, HTN, OSA, and GERD resolution rates were 79% 68.2%, 63.7%, 60%, and 52.7%, respectively. The ending mean weight and BMI were 188.3 ± 41.5 lbs and 30.5 ± 6.5 kg/m2, respectively. The mean %EWL and %TWL at five year were 79.3 ± 25 and 35.9 ± 10.4, respectively. The mean change in BMI was 17.4 ± 6.4 kg/m2. The overall mortality rate was 0.4%.


Laparoscopic SADI-S is effective in achieving weight loss and in improving comorbidities.