It is reported that beige-fat cells have a thermogenic mechanism built around a creatinine-driven substrate cycle. We studied the association between creatinine and weight on overweight women in outpatient clinic. Therefore, we investigated whether creatinine was related with general and central obesity in general population.
We conducted 7,772 subjects (41.9+/- 22.9 years, 22.7 +/- 4.3 kg/m2, Waist circumference 78.0 +/-14.3 cm, Women 55%) recruited and checked serum creatinine in 2016 Korea National Health Analysis Nutrition Examination Survey (KNHANES).Fasting plasma glucose, and total cholesterol, HDL cholesterol, triglyceride, and waist circumferences, height, and weight, waist circumference (WC) were evaluated after overnight fasting for 8 hours at initial visit. We investigated the association between creatinine and obesity indicators such as waist and BMI.The statistical Pearson’s correlation and student’s t-test were performed by SPSS package for windows version 18.The probability less than 0.05 was considered as significant at both sided.
Creatinine was significantly correlated with BMI (p= .007), WC (p=.073) after adjusted for age, sex, and alcohol, smoking, exercise, and combined disease (DM, hypertension, hyperlipidemia), and blood pressure, fasting blood sugar, lipid profiles.
Well-controlled clinical trial would be needed in the future. In conclusion, creatinine is major determinant related with general obesity (BMI).