Background

The prevalence of metabolic syndrome is increasing in Korea, particularly among young adults. This trend will lead to future cardiovascular and metabolic diseases. Therefore, early detection of metabolic abnormalities and their prevention in early life are imperative. Here, we established a hospital-based biobank cohort for identifying the most prevalent dysmetabolic phenotype. The aim of this study is to inform other researchers of our protocol and to share our data for future collaboration.

Methods

The baseline examination included health-related questionnaires, anthropometric measurements and handgrip strength, analysis of body composition by bioelectrical impedance analysis, and nutritional assessment. Relevant biochemical parameters were measured, and oral glucose tolerance tests were performed. Metabolic syndrome was defined according to the National Cholesterol Education Program Adult Treatment Panel III criteria with Asian waist circumference criteria.

Results

From around 3000 employees aged 20-59 years working at Seoul National University Bundang Hospital, 1,017 subjects were enrolled in 2015-2016. The mean age was 34.5±8.4 years for men (n = 311; 30.6%) and 30.9±8.5 years for women (n = 706; 69.4%). The overall prevalence of metabolic syndrome was 7.6% (17.7% in men and 3.1% in women). Among five components, high blood pressure was the most prevalent in men (51.4%) and women (13.8%), respectively.

Conclusions

Although further follow-up data are needed, we expect that more adverse cardiovascular events might occur in men than in women. This hospital-based cohort will serve as a foundation for the comprehensive evaluation of metabolic syndrome and future cardiometabolic diseases in middle-aged Korean.