Diabetesisthe metabolicdisorder inIndiabecausemorethan62milliondiabeticindividualscurrentlydiagnosedwiththediseasewhichischaracterizedbyhyperglycemiaduetodefectsintheinsulin secretionorsensitivityorboth.


Inthetype 2diabetes mellitus patients, the “Metformin” is considered as gemstone due to its numerous clinical benefits like better glycemic control, use in treatment of polycystic ovary syndrome, act as protective agent in cardiovascular disease especially in arthrosclerosis patients when it is associated with chronic kidney disease. Instead of its beneficial effects it may cause some consequences like dwindling or elevation in the level of folic acid, vitamin B12, vitamin D etc.Therapeutic options may be a problem in diabetes mellitus patients because it require adjustment of doses.


There are thirty cases have been reported inwhich patients taking metformin and by reviewing the literature on the basis of clinical presentation, diagnosis and therapeutic approach the cases illustrates decrease in level of folic acid, vitamin B12,vitamin D, increase in level of triglycerides,LDL but the HDL level diminishes.


In conclusion it is observed that patients who are on metformin have declined a level of folic acid, vitamin D with elevated level of triglycerides, LDL and HDL level also dwindled. Apart from this observation, it is also seen that it is mostly taking place in females as compared to males.