Background

Hypertension is strongly correlated with increased risk for chronic kidney failure, arterial aneurysm, and cerebral and cardiovascular events. Recent studies have demonstrated body fat percentage (BF%) are associated with cardiometabolic risk factors. The aim of this study was to investigate the association between a change of BF% and new-onset hypertension, and the body mass index(BMI) to the development of hypertension in a normotensive Korean cohort.

Methods

At baseline (2001-2002), 8848 participants aged 40-70 years were recruitedthe study, with follow-up surveys completed in 2014. 3,902 adults (1,866 men and 2,036 women) were included in final analysis. 3902 subjects were divided into quartile groups by change of body fat percentage (BF%) followed up for 8.4 years to monitor the development of hypertension. Logistic regression model was used to evaluated the relative risk(RR) for hypertension according to BF% change quartile. Additionally, we also stratified participants into four groups according to BMI change levels.

Results

In adjusted model, compared to the BF% quartile 1 group, the risk for new onset hypertension significantly increased over BF% change 0- 2.0%, quartile3 (RR:1.32(1.06-1.63)) and BF% change 2.0- 8.9%, quartile4(RR:1.78(1.43-2.19)). In additional analysis, the relative risk(RR) for new onset hypertension compared with a quartile 1 group (change of BMI-6.80- -0.86% (kg/m2)) were 1.81(95% CI: 1.47-2.21) quartile4, for a gain of BMI 0.91-13.2%(kg/m2).

Conclusions

Body fat gain and BMI increase were independent predictor of hypertension in this community based Korean cohort.