Obesity is one of the causes of metabolic disorders. Bariatric surgery confers beneficial effects not only on body weight but also on metabolic disorders. Lipoprotein lipase level in preheparin serum (preheparin LPL level) is associated with visceral adipose tissue and reflects insulin resistance. However, the change in serum preheparin LPL levels after bariatric surgery remains unclear. This study aimed to examine the effect of bariatric surgery on preheparin LPL level in patients with obesity.


We retrospectively reviewed a total of 86 patients with obesity who received bariatric surgery and were measured preheparin LPL level before and 12 months after bariatric surgery. Surgical procedure was sleeve gastrectomy (n=72), sleeve gastrectomy with duodenal-jejunal bypass (n=9) and gastric bypass (n=5). We examined clinical parameters such as body mass index (BMI), hemoglobin A1c (HbA1c), and preheparin LPL level before and 12 months after bariatric surgery.


BMI and HbA1c decreased significantly after bariatric surgery. Lipid parameters such as triglyceride, high-density lipoprotein cholesterol (HDL-C) and low-density lipoprotein cholesterol were also significantly improved after bariatric surgery. Preheparin LPL level increased significantly after bariatric surgery (from 45.3 ± 20.9 to 70.6 ± 31.9 ng/ml, P < 0.0001). The simple linear regression showed that increase of preheparin LPL level was significantly correlated with increase of HDL-C level. The multiple regression model identified a change in HDL-C as an independent predictor for a change in preheparin LPL level.


Bariatric surgery results in increased HDL-C probably due to increased LPL.